Down's Syndrome with Alzheimer's Disease-Like Pathology: What Can It Teach Us about the Amyloid Cascade Hypothesis?

1Department of Pathology, MD Anderson Cancer Institute, 1515 Holcombe Boulevard, Houston, TX 77030, USA 2Department of Pathology and Laboratory Medicine, College of Medicine, University of Cincinnati, MSB, 231 Albert Sabin Way, Cincinnati, OH 45221, USA 3Department of Pediatrics and Internal Medicine, College of Medicine, University of Cincinnati, MSB, 231 Albert Sabin Way, Cincinnati, OH 45221, USA 4Department of Neurosurgery, College of Medicine, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45221, USA